The Effect of Erythropoietin on Ovarian Congestion during Ischemia Reperfusion Injury in Rats

Background: This experimental study examined the effect of erythropoietin (epoetin alfa) on rat model and particularly in an ovarian ischemia reperfusion (IR) protocol. The effects of that molecule were studied pathologically using mean ovarian congestion (OC) lesions. Materials and methods: 40 rats of mean weight 247.7 g, 16-18 weeks old, were used in the study. OC lesions were evaluated after 45 min ischemia, at 60 min (groups A and C) and at 120 min (groups B and D) of reperfusion. Erythropoietin was administered only in groups C and D. Results: Epo administration kept non-significantly increased the OC scores without lesions (p = 0.2954). Reperfusion time kept nonsignificantly increased the OC scores without lesions (p = 0.8063). However, Epo administration and reperfusion time together kept non-significantly increased the OC scores without lesions (p = 0.3882). Conclusions: Epo administration, reperfusion time and their interaction kept non-significantly increased the OC scores. Epo short-term restored the congestive lesions from significant to nonsignificant level.